Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial.
Identifieur interne : 000030 ( Main/Exploration ); précédent : 000029; suivant : 000031Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial.
Auteurs : Vincent Meininger [France] ; Angela Genge [Canada] ; Leonard H. Van Den Berg [Pays-Bas] ; Wim Robberecht [Belgique] ; Albert Ludolph [Allemagne] ; Adriano Chio [Italie] ; Seung H. Kim [Corée du Sud] ; P Nigel Leigh [Royaume-Uni] ; Matthew C. Kiernan [Australie] ; Jeremy M. Shefner [États-Unis] ; Claude Desnuelle [France] ; Karen E. Morrison [Royaume-Uni] ; Susanne Petri [Allemagne] ; Diane Boswell [Royaume-Uni] ; Jane Temple [Royaume-Uni] ; Rajat Mohindra [Royaume-Uni] ; Matt Davies [Royaume-Uni] ; Jonathan Bullman [Royaume-Uni] ; Paul Rees [Royaume-Uni] ; Arseniy Lavrov [Royaume-Uni]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2017.
Abstract
Neurite outgrowth inhibitor A (Nogo-A) is thought to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). A monoclonal antibody against Nogo-A showed a positive effect in the SOD1(G93A) mouse model of ALS, and a humanised form of this antibody (ozanezumab) was well tolerated in a first-in-human trial. Therefore, we aimed to assess the safety and efficacy of ozanezumab in patients with ALS.
DOI: 10.1016/S1474-4422(16)30399-4
PubMed: 28139349
Affiliations:
- Allemagne, Australie, Belgique, Canada, Corée du Sud, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Arizona, Bade-Wurtemberg, Basse-Saxe, District de Tübingen, Midlands de l'Ouest, Piémont, Provence-Alpes-Côte d'Azur, Sussex de l'Est, Utrecht (province), Île-de-France
- Birmingham, Brighton, Falmer, Hanovre, Nice, Paris, Séoul, Turin, Ulm, Utrecht
- Université d'Ulm, Université de Birmingham, Université du Sussex
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000049
- to stream PubMed, to step Curation: 000049
- to stream PubMed, to step Checkpoint: 000049
- to stream Ncbi, to step Merge: 002208
- to stream Ncbi, to step Curation: 002208
- to stream Ncbi, to step Checkpoint: 002208
- to stream Main, to step Merge: 000030
- to stream Main, to step Curation: 000030
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial.</title><author><name sortKey="Meininger, Vincent" sort="Meininger, Vincent" uniqKey="Meininger V" first="Vincent" last="Meininger">Vincent Meininger</name><affiliation wicri:level="3"><nlm:affiliation>Ramsay Generale de Sante Hopital Prive Peupliers, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ramsay Generale de Sante Hopital Prive Peupliers, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Genge, Angela" sort="Genge, Angela" uniqKey="Genge A" first="Angela" last="Genge">Angela Genge</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><affiliation wicri:level="1"><nlm:affiliation>KU Leuven, Department of Neurosciences, Experimental Neurology University Hospitals Leuven, Department of Neurology, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>KU Leuven, Department of Neurosciences, Experimental Neurology University Hospitals Leuven, Department of Neurology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Ludolph, Albert" sort="Ludolph, Albert" uniqKey="Ludolph A" first="Albert" last="Ludolph">Albert Ludolph</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Kim, Seung H" sort="Kim, Seung H" uniqKey="Kim S" first="Seung H" last="Kim">Seung H. Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hanyang University Medical Center, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Hanyang University Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name><affiliation wicri:level="4"><nlm:affiliation>Division of Medicine (Neurology), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, East Sussex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Medicine (Neurology), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, East Sussex</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Kiernan, Matthew C" sort="Kiernan, Matthew C" uniqKey="Kiernan M" first="Matthew C" last="Kiernan">Matthew C. Kiernan</name><affiliation wicri:level="1"><nlm:affiliation>Brain & Mind Centre, Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Brain & Mind Centre, Sydney Medical School, the University of Sydney, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Shefner, Jeremy M" sort="Shefner, Jeremy M" uniqKey="Shefner J" first="Jeremy M" last="Shefner">Jeremy M. Shefner</name><affiliation wicri:level="2"><nlm:affiliation>Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Desnuelle, Claude" sort="Desnuelle, Claude" uniqKey="Desnuelle C" first="Claude" last="Desnuelle">Claude Desnuelle</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital of Nice, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Nice, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E" last="Morrison">Karen E. Morrison</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Petri, Susanne" sort="Petri, Susanne" uniqKey="Petri S" first="Susanne" last="Petri">Susanne Petri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Boswell, Diane" sort="Boswell, Diane" uniqKey="Boswell D" first="Diane" last="Boswell">Diane Boswell</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Temple, Jane" sort="Temple, Jane" uniqKey="Temple J" first="Jane" last="Temple">Jane Temple</name><affiliation wicri:level="1"><nlm:affiliation>R&D Projects Clinical Platforms and Sciences, Quantitative Sciences, Clinical Statistics, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>R&D Projects Clinical Platforms and Sciences, Quantitative Sciences, Clinical Statistics, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Mohindra, Rajat" sort="Mohindra, Rajat" uniqKey="Mohindra R" first="Rajat" last="Mohindra">Rajat Mohindra</name><affiliation wicri:level="1"><nlm:affiliation>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Matt" sort="Davies, Matt" uniqKey="Davies M" first="Matt" last="Davies">Matt Davies</name><affiliation wicri:level="1"><nlm:affiliation>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Bullman, Jonathan" sort="Bullman, Jonathan" uniqKey="Bullman J" first="Jonathan" last="Bullman">Jonathan Bullman</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Stevenage, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Stevenage</wicri:regionArea><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Rees, Paul" sort="Rees, Paul" uniqKey="Rees P" first="Paul" last="Rees">Paul Rees</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Lavrov, Arseniy" sort="Lavrov, Arseniy" uniqKey="Lavrov A" first="Arseniy" last="Lavrov">Arseniy Lavrov</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK. Electronic address: arseniy.j.lavrov@gsk.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28139349</idno><idno type="pmid">28139349</idno><idno type="doi">10.1016/S1474-4422(16)30399-4</idno><idno type="wicri:Area/PubMed/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000049</idno><idno type="wicri:Area/PubMed/Curation">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000049</idno><idno type="wicri:Area/PubMed/Checkpoint">000049</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000049</idno><idno type="wicri:Area/Ncbi/Merge">002208</idno><idno type="wicri:Area/Ncbi/Curation">002208</idno><idno type="wicri:Area/Ncbi/Checkpoint">002208</idno><idno type="wicri:Area/Main/Merge">000030</idno><idno type="wicri:Area/Main/Curation">000030</idno><idno type="wicri:Area/Main/Exploration">000030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial.</title><author><name sortKey="Meininger, Vincent" sort="Meininger, Vincent" uniqKey="Meininger V" first="Vincent" last="Meininger">Vincent Meininger</name><affiliation wicri:level="3"><nlm:affiliation>Ramsay Generale de Sante Hopital Prive Peupliers, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ramsay Generale de Sante Hopital Prive Peupliers, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Genge, Angela" sort="Genge, Angela" uniqKey="Genge A" first="Angela" last="Genge">Angela Genge</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><affiliation wicri:level="1"><nlm:affiliation>KU Leuven, Department of Neurosciences, Experimental Neurology University Hospitals Leuven, Department of Neurology, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>KU Leuven, Department of Neurosciences, Experimental Neurology University Hospitals Leuven, Department of Neurology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Ludolph, Albert" sort="Ludolph, Albert" uniqKey="Ludolph A" first="Albert" last="Ludolph">Albert Ludolph</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Kim, Seung H" sort="Kim, Seung H" uniqKey="Kim S" first="Seung H" last="Kim">Seung H. Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hanyang University Medical Center, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Hanyang University Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name><affiliation wicri:level="4"><nlm:affiliation>Division of Medicine (Neurology), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, East Sussex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Medicine (Neurology), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, East Sussex</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Kiernan, Matthew C" sort="Kiernan, Matthew C" uniqKey="Kiernan M" first="Matthew C" last="Kiernan">Matthew C. Kiernan</name><affiliation wicri:level="1"><nlm:affiliation>Brain & Mind Centre, Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Brain & Mind Centre, Sydney Medical School, the University of Sydney, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Shefner, Jeremy M" sort="Shefner, Jeremy M" uniqKey="Shefner J" first="Jeremy M" last="Shefner">Jeremy M. Shefner</name><affiliation wicri:level="2"><nlm:affiliation>Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Desnuelle, Claude" sort="Desnuelle, Claude" uniqKey="Desnuelle C" first="Claude" last="Desnuelle">Claude Desnuelle</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital of Nice, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Nice, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E" last="Morrison">Karen E. Morrison</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Petri, Susanne" sort="Petri, Susanne" uniqKey="Petri S" first="Susanne" last="Petri">Susanne Petri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Boswell, Diane" sort="Boswell, Diane" uniqKey="Boswell D" first="Diane" last="Boswell">Diane Boswell</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Temple, Jane" sort="Temple, Jane" uniqKey="Temple J" first="Jane" last="Temple">Jane Temple</name><affiliation wicri:level="1"><nlm:affiliation>R&D Projects Clinical Platforms and Sciences, Quantitative Sciences, Clinical Statistics, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>R&D Projects Clinical Platforms and Sciences, Quantitative Sciences, Clinical Statistics, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Mohindra, Rajat" sort="Mohindra, Rajat" uniqKey="Mohindra R" first="Rajat" last="Mohindra">Rajat Mohindra</name><affiliation wicri:level="1"><nlm:affiliation>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Matt" sort="Davies, Matt" uniqKey="Davies M" first="Matt" last="Davies">Matt Davies</name><affiliation wicri:level="1"><nlm:affiliation>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Bullman, Jonathan" sort="Bullman, Jonathan" uniqKey="Bullman J" first="Jonathan" last="Bullman">Jonathan Bullman</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Stevenage, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Stevenage</wicri:regionArea><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Rees, Paul" sort="Rees, Paul" uniqKey="Rees P" first="Paul" last="Rees">Paul Rees</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author><author><name sortKey="Lavrov, Arseniy" sort="Lavrov, Arseniy" uniqKey="Lavrov A" first="Arseniy" last="Lavrov">Arseniy Lavrov</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge, UK. Electronic address: arseniy.j.lavrov@gsk.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline, Uxbridge</wicri:regionArea><wicri:noRegion>Uxbridge</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurite outgrowth inhibitor A (Nogo-A) is thought to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). A monoclonal antibody against Nogo-A showed a positive effect in the SOD1(G93A) mouse model of ALS, and a humanised form of this antibody (ozanezumab) was well tolerated in a first-in-human trial. Therefore, we aimed to assess the safety and efficacy of ozanezumab in patients with ALS.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Arizona</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Tübingen</li><li>Midlands de l'Ouest</li><li>Piémont</li><li>Provence-Alpes-Côte d'Azur</li><li>Sussex de l'Est</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Brighton</li><li>Falmer</li><li>Hanovre</li><li>Nice</li><li>Paris</li><li>Séoul</li><li>Turin</li><li>Ulm</li><li>Utrecht</li></settlement><orgName><li>Université d'Ulm</li><li>Université de Birmingham</li><li>Université du Sussex</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Meininger, Vincent" sort="Meininger, Vincent" uniqKey="Meininger V" first="Vincent" last="Meininger">Vincent Meininger</name></region><name sortKey="Desnuelle, Claude" sort="Desnuelle, Claude" uniqKey="Desnuelle C" first="Claude" last="Desnuelle">Claude Desnuelle</name></country><country name="Canada"><noRegion><name sortKey="Genge, Angela" sort="Genge, Angela" uniqKey="Genge A" first="Angela" last="Genge">Angela Genge</name></noRegion></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name></region></country><country name="Belgique"><noRegion><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ludolph, Albert" sort="Ludolph, Albert" uniqKey="Ludolph A" first="Albert" last="Ludolph">Albert Ludolph</name></region><name sortKey="Petri, Susanne" sort="Petri, Susanne" uniqKey="Petri S" first="Susanne" last="Petri">Susanne Petri</name></country><country name="Italie"><region name="Piémont"><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name></region></country><country name="Corée du Sud"><noRegion><name sortKey="Kim, Seung H" sort="Kim, Seung H" uniqKey="Kim S" first="Seung H" last="Kim">Seung H. Kim</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name></region><name sortKey="Boswell, Diane" sort="Boswell, Diane" uniqKey="Boswell D" first="Diane" last="Boswell">Diane Boswell</name><name sortKey="Bullman, Jonathan" sort="Bullman, Jonathan" uniqKey="Bullman J" first="Jonathan" last="Bullman">Jonathan Bullman</name><name sortKey="Davies, Matt" sort="Davies, Matt" uniqKey="Davies M" first="Matt" last="Davies">Matt Davies</name><name sortKey="Lavrov, Arseniy" sort="Lavrov, Arseniy" uniqKey="Lavrov A" first="Arseniy" last="Lavrov">Arseniy Lavrov</name><name sortKey="Mohindra, Rajat" sort="Mohindra, Rajat" uniqKey="Mohindra R" first="Rajat" last="Mohindra">Rajat Mohindra</name><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E" last="Morrison">Karen E. Morrison</name><name sortKey="Rees, Paul" sort="Rees, Paul" uniqKey="Rees P" first="Paul" last="Rees">Paul Rees</name><name sortKey="Temple, Jane" sort="Temple, Jane" uniqKey="Temple J" first="Jane" last="Temple">Jane Temple</name></country><country name="Australie"><noRegion><name sortKey="Kiernan, Matthew C" sort="Kiernan, Matthew C" uniqKey="Kiernan M" first="Matthew C" last="Kiernan">Matthew C. Kiernan</name></noRegion></country><country name="États-Unis"><region name="Arizona"><name sortKey="Shefner, Jeremy M" sort="Shefner, Jeremy M" uniqKey="Shefner J" first="Jeremy M" last="Shefner">Jeremy M. Shefner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000030 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000030 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28139349
|texte= Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28139349" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |